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86-4042-48Anti-Ebola virus EBOVsubtype Zaire strain Mayinga 1976 GlycoproteinGP Polyclonal Antibody 100uL E-AB-V1134

86-4042-48Anti-Ebola virus EBOVsubtype Zaire strain Mayinga 1976 GlycoproteinGP Polyclonal Antibody 100uL E-AB-V1134

品番: etG6rWfLjzqBS1i

冷凍 【輸入試薬に関するお問合せ】 アズワン株式会社 輸入試薬グループ TEL:06-6447-8641 FAX:06-6447-8642 E-mail: 特徴 背景:The fourth gene of the EBOV genome encodes a 16-kDa e...
76,000円  27,080円割引: 64%OFF

アイテム説明

  • 冷凍

  • 【輸入試薬に関するお問合せ】
  • アズワン株式会社 輸入試薬グループ
  • TEL:06-6447-8641
  • FAX:06-6447-8642
  • E-mail:

特徴

  • 背景:The fourth gene of the EBOV genome encodes a 16-kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.

仕様

  • アプリケーション:WB,ELISA
  • 交差性:Ebola virus
  • 宿主:Rabbit
  • アイソタイプ:IgG
  • 抗原:Recombinant EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP Protein (His Tag)
  • 緩衝液:0.2 μm filtered solution in PBS
  • 精製方法:Antigen Affinity
  • 希釈倍率:WB 1:500-1:2000 ELISA 1:5000-1:10000
  • 標識:Unconjugated
  • メーカーマニュアルリンク:https://file.elabscience.com/viewpdf-456979-Elabscience-E-AB-V1134.pdf
  • サイズ:100uL
  • この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)

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